What Is Zofran Injection Used For?

Did you wake up feeling nauseous after a night out? That spinning room, the dry heaving, the regret—we get it. At Treadwell Houston, we use Zofran injections mainly to help with hangover-related nausea so you can bounce back faster and get on with your day.
Forget the old-school hangover cures. Zofran goes straight to the source. Ondansetron, the active ingredient in Zofran injectable, works by blocking the chemicals in the body that trigger nausea, so you don’t have to spend the whole day hugging a toilet or curling up on the couch.
How Zofran Injections Work
Your body releases serotonin when exposed to chemotherapy, radiation, or anesthesia. Too much serotonin can trigger nausea and vomiting. Zofran injectable blocks serotonin from activating receptors in your brain and gut, stopping nausea before it starts. It makes it a popular choice for patients undergoing intense treatments that commonly cause stomach upset.
Who Needs Zofran Injections?
At Treadwell Houston, most of our clients come in for Zofran injections to deal with hangover nausea—and they swear by how fast it works. But this powerful anti-nausea shot isn’t just for the morning after. Doctors also use it in hospitals to treat nausea caused by serious medical treatments.
Here’s a breakdown of when and why people usually turn to Zofran:

1. Chemotherapy or Radiation Side Effects
Outside of our hangover crowd, Zofran is also used to prevent nausea in people going through chemo or radiation. These treatments often trigger intense stomach upset, and Zofran helps patients tolerate them better.
2. Hangover Relief
Had one too many last night? Zofran injections help stop that wave of nausea, settle your stomach, and get you back on your feet—fast. Whether it’s brunch, work, or life waiting for you, we’ll help you feel normal again.
3. People Recovering from Surgery
Anesthesia can leave people feeling dizzy and nauseous after surgery. Zofran injectable is often given before or right after surgery to keep nausea at bay.
4. Children and Older Adults
Children over 6 months old can receive Zofran injections for chemotherapy-related nausea. Elderly patients can also use it safely, but doctors might adjust the dose based on their overall health.
How We Give Zofran Injections at Treadwell Houston
Our trained team gives the injection safely and makes sure it works. You can get it two ways:
- IV (Intravenous) – Goes right into your vein for fast relief
- IM (Intramuscular) – Into your muscle for a more gradual effect
We’ll recommend what’s best for you based on your feelings.
When Will I Get It?
Timing depends on your symptoms—but here’s how it usually goes:
- Woke up nauseous after drinking? Come in first thing—we’ll get you taken care of.
- Feeling queasy before a big event? Come in as soon as you can. The faster we treat it, the better you’ll feel.
Who Should Avoid Zofran Injectable?

While Zofran injections in Houston help many people, some should be cautious when using them.
1. People with Heart Conditions
This medication can affect heart rhythm. If you have irregular heartbeats or long QT syndrome, consult your doctor before getting a Zofran injection.
2. Patients with Liver Disease
Your liver processes Zofran injectable, so if you have severe liver disease, your doctor might adjust your dose or suggest an alternative.
3. People Taking Certain Medications
Some drugs interact badly with Zofran injections, including:
- Apomorphine (used for Parkinson’s disease) – Can cause dangerous drops in blood pressure.
- Antidepressants (SSRIs, SNRIs) – Can increase the risk of serotonin syndrome.
- Heart medications that affect QT interval – May increase the risk of irregular heartbeat.
Always tell your doctor about any prescription or over-the-counter medications before receiving Treadwell Houston’s Zofran injectable.
Possible Side Effects
Most people tolerate Zofran injections well, but side effects can happen.
Common Side Effects
- Headache
- Fatigue
- Constipation or diarrhea
Serious Side Effects (Call a Doctor Right Away If You Have These)
- Allergic reactions – Your face, lips, tongue, or throat may swell.
- Heart rhythm problems – Fast, irregular heartbeat, dizziness, or fainting.
- Serotonin syndrome – High fever, muscle stiffness, confusion, sweating.
If you notice severe side effects, contact your doctor immediately.
How to Store Zofran Injectable
- Keep it in a room temperature setting, between 59°F and 86°F.
- Store in a cool, dry place away from light.
- Keep it out of children’s reach.
Final Thoughts
You don’t need to suffer through a hangover. Zofran injections at Treadwell Houston give you fast, effective relief so you can feel like yourself again. Whether you had one too many or just didn’t eat enough before the night kicked off, we’re here to help you recover—fast and smooth.
Struggling with Nausea? Get Relief Today at Treadwell Houston!
Don’t let nausea slow your recovery. Talk to your doctor about Zofran injections for fast relief. Need expert advice? Treadwell Houston is here to help—book a consultation now!

FAQs
How long does it take for a Zofran injection to work?
Most people feel relief within 30 minutes to an hour after getting the injection.
Can I get Zofran injections at home?
No, a doctor or nurse must administer the injection in a hospital or clinic. If you’re looking for expert care and guidance, Treadwell Houston provides professional medical support to ensure safe and effective treatment.
Can I eat or drink anything before or after getting a Zofran injection?
There are no strict food or drink restrictions, but following your doctor’s advice is best.